Any input, any output
Plug in a class-compliant interface and every channel it has can become an input or an output on the canvas. You can connect a guitar, a bass, a synth, a microphone or a modular rig over several channels, or use an audio file as the source.
In a DAW, irio pro runs as an AUv3 effect on a track or a bus. Look for it in the list of effects, not instruments.